Low Dose Naltrexone (LDN) and MS: What You Need to Know

If you’ve been living with multiple sclerosis (MS) for a while, you’ve probably heard about Low Dose Naltrexone (LDN)—a treatment that’s been gaining attention for its potential benefits in managing MS symptoms.

LDN isn’t a mainstream MS treatment, but many people with MS have found it helps with pain, fatigue, and overall well-being. While research is still limited, the anecdotal evidence is strong, and some doctors are beginning to take notice.

So, what exactly is LDN, how does it work, and could it be a good option for you? Let’s dive in.

A short history of Low Dose Naltrexone

LDN is a low-dose version of Naltrexone, a drug originally approved by the FDA in 1984 to treat opioid and alcohol addiction.

In the mid-1980s, Dr. Bernard Bihari discovered that lower doses of Naltrexone (typically 1.5 to 4.5 mg) had unexpected benefits for people with autoimmune diseases, including MS.

Since then, LDN has been used off-label to help manage symptoms of MS, fibromyalgia, Crohn’s disease, and other chronic conditions.

How Does LDN Work for MS?

LDN works by blocking opioid receptors in the brain for a short period, which triggers the body to increase endorphin production.

Endorphins are natural painkillers and play a role in immune system regulation. Since MS is an autoimmune disease, boosting endorphins may help reduce inflammation and slow disease progression.

LDN is believed to:

• Reduce inflammation in the central nervous system.
• Improve pain management by increasing endorphins.
• Enhance mood and cognitive function.
• Support overall well-being.

While LDN isn’t a disease-modifying therapy (DMT)—meaning it doesn’t stop MS progression—it may help manage symptoms and improve quality of life.

Trying to Get LDN:
The Struggle for a Prescription

Despite its potential benefits, getting a prescription for LDN can be challenging.

When Cir first looked into LDN back in 2004, none of his doctors would prescribe it. Since LDN was only FDA-approved at 50 mg for addiction treatment, many neurologists were hesitant to prescribe it for MS.

Cir’s general practitioner (GP) was open to the idea but wanted a neurologist's approval first. Unfortunately, Cir's neurologist refused, saying there was no clinical evidence to support its use for MS.

Fast forward to today, and more doctors are recognizing LDN’s potential. Some clinics are even participating in clinical trials to study its effects on MS.

If you’re interested in trying LDN, here are some tips for getting a prescription:

Minimal Side Effects: What to Expect

• Find a doctor familiar with LDN—some naturopaths and integrative medicine specialists prescribe it.
• Bring research and patient testimonials to your neurologist.
• Consider compounding pharmacies that specialize in LDN.

One of the biggest advantages of LDN is its low risk of side effects.

Most MS medications come with serious side effects, but LDN is generally well-tolerated. Some people experience:

• Vivid dreams or difficulty sleeping when first starting.
• Mild nausea or dizziness.
• Temporary headaches.

These side effects usually fade within a few weeks and adjusting the dose when you first start taking it can help.

Does LDN Actually Work for MS?

The research on LDN for MS is limited, but some studies suggest it may help reduce symptoms like pain, fatigue, and cognitive issues.

A 2010 study involving 80 people with MS found that LDN improved mental health and overall quality of life. It didn’t significantly impact physical symptoms, however.

Another 2017 study looked at prescription data and found no major differences in medication use between MS patients who took LDN and those who didn’t.

Despite mixed results, many people with MS swear by LDN, saying it helps them feel better overall.

Cir has been taking LDN since 2004, and he notices a difference when he misses a dose. While it hasn’t cured his MS, it has helped him maintain stability and feel more energized.

Update: As of now - 2025 - Cir hasn't taken LDN for several years. He hasn't progressed to the point of total disability, however, though he does now need a mobility aide such as a walker, rollator, or wheelchair to get around.

How to Get LDN If Your Doctor Won’t Prescribe It

If your doctor refuses to prescribe LDN, you still have options:

• Find a compounding pharmacy that specializes in LDN.
• Look for online telemedicine services that prescribe LDN.
• Join LDN support groups to find doctors who prescribe it.

Some websites, like the LDN Research Trust, provide resources and doctor directories to help patients access LDN.

Final Thoughts:
Is LDN Right for You?

LDN isn’t a miracle cure, but for many people with MS, they feel it’s a game-changer.

If you’re struggling with pain, fatigue, or cognitive issues, LDN might be worth exploring—especially since it has minimal side effects.

The key is to do your research, talk to your doctor, and once you start taking it, listen to your body to see if it makes a difference. Most insurance won't cover it, so you'll need to add the cost to your monthly budget.

You can find more information about LDN for MS here and here.

LDN Videos

Here are a few video interviews of people who have tried ldn and have gotten good results. We were excited to see them and thought you would enjoy watching them also.

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