I have had MS for 14 years, went from RRMS to SPMS about 4 years ago, which is when I really started to go downhill, now in a wheelchair. Have not taken any medications other than IV Methylprednisolone occassionally.
Started LDN 4 months ago, now 4.5mg nightly. Have not had any side-effects or seen much in the way of symptom abatement. However I'm mainly taking it to arrest the progression of the disease. I've found I have more bowel and bladder control and if it does no more than that I'm happy.